the internet certainly is fascinating. (maybe not as much as the inner nut, that guy who's running loose in my head.) I went to my google page and let my hands fall freely on the keyboard without looking. this what I got: ]mermgb...so I googled it. sure enough it turns out to be something:
A method for detecting a target sequence in a polynucleotide,wherein the polynucleotide is present in a mixture comprising a plurality of polynucleotides that do not contain the target sequence, and wherein the target sequence differs by only a single nucleotide from one or more sequences in thenon-target polynucleotides, the method comprising:(a) providing a Minor Groove Binder (MGB)-oligonucleotide conjugate, wherein the sequence of the oligonucleotide is perfectly complementary to the target sequence;(b) incubating the MGB-oligonucleotide conjugate and the mixture under hybridization conditions; and(c) detecting polynucleotides which preferentially hybridize to the MGB-oligonucleotide conjugate, whereby a polynucleotide which preferentially hybridizes to the MGB-oligonucleotide conjugate contains the target sequence.
a minor groove binder...how about that,
you learn something new every day.